After enabling "High DPI Aware" on High DPI Surface Pro (zoom 200%), UI became unusable as It was unusable with wx3.0 (wx3.0 was not having high DPI support).
With wx3.1, application layout works fine but it is coming blur, to solve the blur issue I did the manifest changes to make my application DPI-aware, it removed the blur effect but application layout went wrong, every layout looks smaller (unusable UI).
Interestingly, on another non-high dpi system where zoom level was 125%, was also facing the blur issue. But manifest file change mentioned by you solved the issue.
Note* issue more vigilant on 3K and 4K system. Hardcoded pixel sizes are not scaling (like 400px width button, 500pixel width panel etc).