If you are using the main C++ distribution of wxWidgets, Feel free to ask any question related to wxWidgets development here. This means questions regarding to C++ and wxWidgets, not compile problems.
If your window is a wxFrame, I would suggest wxSashLayoutWindow which you can find in the sash test sample. That's a better way of splitting then using splitters which are really meant for simple splitting (and have their quirks)..
Yes the main frame shoid be a wxFrame (as I need a menu, a toolbar and a statusbar), the thing is that I need to split the frame vertically, and then split each pan it horizontally 2 times. This figure will demontrate what I need: